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Longevity Medicine: What If You Started With What You Want to Change?

Published October 8, 2026 · 18 min read

Longevity Medicine: What If You Started With What You Want to Change?

Search for longevity medicine and you get a list.

Metformin. NAD+. Peptides. A dozen supplements. Every one of them "the most promising".

What if the list is the problem?

Nobody ages in general. You notice one thing first. The energy that does not come back after lunch. The sleep that stopped being deep. The waistline that ignores the gym.

So here is a different way in.

What if you stopped asking "which one is best?" and started with what you want to change?

The short version. Longevity medicine is not one treatment. It is a handful, and each works on a different part of how you age: your energy, your cells, your sleep and recovery, your waistline and heart. None has been shown to add years to a healthy life, because that trial would take decades. Several have changed things people can feel or measure. This guide covers the seven we offer, from $25 to $299 a month, and points you to the full article on each.

What is longevity medicine?

Longevity medicine is care aimed at how well you age, not only at illness once it arrives.

Doctors have a word for the goal: healthspan. It means the years you spend strong, clear-headed and independent.

Two people can both be 60 and be very different ages inside. One takes the stairs without a thought. The other plans around them. Longevity medicine is about which of those you become.

Here is what nobody selling it should hide. No medicine is approved to slow aging. Aging is not classed as a disease, so there is no standard route for testing a treatment against it. And a trial that proved people live longer would take most of a lifetime to run.

Researchers know this. Their workaround is the TAME trial, designed to follow more than 3,000 adults aged 65 to 79 on metformin for six years and count diseases in place of deaths. The design is ready. The funding is not.

So "not proven" does not mean "disproven". It means the proof takes longer than the question has existed.

What can you do in the meantime? Work on the parts of aging you can feel and measure now.

How to read this guide

Every treatment below gets the same four lines.

  • What is known. What studies in people have found.
  • What if. The open question that makes it interesting.
  • It suits you if. Who tends to ask for it.
  • At Goprolean. What it costs, and where to read the full article.

We offer all seven. We would rather show you our reasoning than hand you a slogan, so every claim is sourced in the full article it comes from.

Longevity treatments, by what you want to change

"I am tired all the time"

Start with the simplest answer.

Prescription injection
B12 shots
What is known. About one American adult in eight has less B12 than doctors call sufficient, and B12 is not part of routine blood work. If you are low, a shot puts it back without depending on your gut. If your B12 is already fine, studies have not found that more of it adds energy.
What if. What if you are not tired, just running low?
It suits you if you are over 60, on metformin, on an acid reducer for two years or more, or eating little or no meat, fish, eggs or dairy.
At Goprolean. $25 for a one-month supply, telehealth consultation included.
Read Benefits of B12 Shots: What If You Are Not Tired, Just Running Low? · See B12 plans

"I want my cells to have what they had at 30"

Every cell you have runs on a molecule called NAD+. It takes part in about 500 chemical reactions, among them turning food into energy and repairing DNA. There are two ways to go after it.

Prescription injection
NAD+ injections
What is known. In mice, NAD+ falls with age, and old mice given an NAD+ booster have shown stronger muscles and healthier blood vessels. In people, step one works: in a trial of 120 adults aged 60 to 80, a daily booster capsule raised NAD+ in the blood by about 40% to 90%. Whether that slows aging has not been tested yet.
What if. What if you never ran low? Nobody has tested a small, regular supply of NAD+ itself. We think it is the approach that makes the most sense.
It suits you if you want the molecule itself, not an ingredient, and a physician reviewing your history first.
At Goprolean. $299 for a one-month supply, telehealth consultation included.
Read NAD+ Injections and Aging: What If You Never Ran Low? · See NAD+ injection plans
Dietary supplement
NMN capsules
What is known. NMN is the ingredient your body turns into NAD+. A 2024 review counted nine human trials. In the trials that measured it, NMN raised NAD+ in the blood. Some results were encouraging: people walked farther, or faster. A pooled analysis of eight trials found no meaningful change in blood sugar or cholesterol.
What if. What if you could start for under $2 a day?
It suits you if price comes first, or you would rather swallow a capsule than use a needle.
At Goprolean. $55 for a one-month bottle, from our supplements shop. No prescription needed.
Read NMN vs NAD+: What If You Skipped the Ingredient and Took the Real Thing? · See NMN in our supplements shop

"I want to slow the wear and tear"

Prescription injection
Glutathione injections
What is known. Glutathione is your body's main antioxidant, and you make less of it with age. When researchers at Baylor College of Medicine restored it in older adults, in two small studies, they got stronger and walked faster. When they stopped, the gains faded. Those studies gave its building blocks by mouth.
What if. What if you could fill it back up, and keep it topped up? Nobody has yet run the same trial with injections. We think a small, regular injection is the sensible way to take glutathione itself.
It suits you if you want glutathione itself, in a form that skips the gut.
At Goprolean. $57.32 for a one-month supply, telehealth consultation included. That is less than a single clinic drip usually costs.
Read Glutathione Injections: What If You Could Refill Your Master Antioxidant? · See glutathione plans

"My sleep and recovery are not what they were"

Prescription injection
Sermorelin
What is known. From your thirties, growth hormone output falls by about 15% every ten years, and most of it is released in deep sleep. Sermorelin does not add growth hormone. It prompts your own pituitary to release more. In small studies of older adults, levels rose within weeks. Over months, body fat fell about 5%, men gained about 2.8 lb of lean mass, and scores for memory and mental speed improved. Strength did not reliably improve.
What if. What if your body only needed a nudge?
It suits you if you train and eat the way you always have and get less back for it, or your energy has gone flat. It is not for anyone with an active cancer, or anyone pregnant or breastfeeding.
At Goprolean. $195 for a one-month supply, telehealth consultation included.
Read Sermorelin and Aging: What If Your Body Only Needed a Nudge? · See sermorelin plans

"My waistline, my heart, my blood sugar"

This is where the big trials are.

Prescription injection
GLP-1 medications: semaglutide and tirzepatide
What is known. In a trial of 17,604 adults with overweight or obesity and heart disease, heart attacks, strokes and heart deaths were about 20% fewer on semaglutide than on a dummy injection. In adults with obesity and prediabetes, 1.3% of those on tirzepatide went on to type 2 diabetes over about three years, against 13.3% on a dummy injection. Those trials tested the manufacturers' products in people who had those conditions. They did not test whether a GLP-1 medication slows aging in a healthy person.
What if. In 2026 a small trial reported that semaglutide shifted several DNA-based measures of biological age. One small trial, in people with one specific condition. But what if looking after your metabolism is one of the ways you protect your later years?
It suits you if you carry weight that is putting your health at risk. Muscle matters here. In one tirzepatide study, about a quarter of the weight lost was lean tissue, so protein and strength training belong in the plan.
At Goprolean. Compounded semaglutide is $190 and compounded tirzepatide is $239 for a one-month supply, telehealth consultation included. Compounded medications are not FDA-approved.
Read Do GLP-1 Medications Slow Aging? What the Research Shows · See semaglutide · See tirzepatide
Prescription pill
Metformin
What is known. Metformin is the most talked-about longevity drug there is, with a long safety record. In monkeys given it for 40 months, the brain measured about six years younger than expected. On its own it has not delivered. In the most rigorous mouse lifespan test it did nothing alone, and a great deal alongside a second drug. In older adults, it blunted what exercise did for them.
What if. What if it was never meant to work alone? We think it makes the most sense at a low dose, as a partner to NAD+ and to GLP-1 medications. Nobody has tested that combination yet.
It suits you if your stomach tolerates it. About 30% of people get stomach side effects. Metformin is FDA-approved for type 2 diabetes, and using it for healthy aging is an off-label use that a physician decides on.
At Goprolean. $25 for a one-month supply, telehealth consultation included.
Read Metformin for Longevity: What If It Was Never Meant to Work Alone? · See metformin

Can you combine them?

People call it a longevity stack, or a longevity protocol. Some of these do belong together.

  • Metformin and B12. Metformin can lower B12 over time. In a large US study, after five years about 1 in 5 people on metformin had low or borderline B12, against 1 in 10 on a dummy pill.
  • Metformin, NAD+ and a GLP-1 medication. A low dose of metformin keeps the part the longevity research is built on. NAD+ covers the one thing metformin may take away. A GLP-1 medication does the heavy lifting on appetite and blood sugar, so the metformin never has to be pushed. What if metformin was never the solo act, but the partner? We make the case in Metformin for Longevity: What If It Was Never Meant to Work Alone?
  • Sermorelin and testosterone therapy. The two are often prescribed together.

Here is the honest part. Nobody has tested a full stack in people. So more is not the goal.

Start with the one thing you want to change. Give it time. Add only what has a reason to be there. A licensed physician reviews your history, and every medication you take, before anything is prescribed.

What each costs at Goprolean

Treatment
Price
What it is
B12 shots
$25 for a one-month supply
Prescription injection
Metformin
$25 for a one-month supply
Prescription pill
NMN capsules
$55 for a one-month bottle
Supplement, from our shop
Glutathione
$57.32 for a one-month supply
Prescription injection
Semaglutide
$190 for a one-month supply
Compounded prescription injection
Sermorelin
$195 for a one-month supply
Prescription injection
Tirzepatide
$239 for a one-month supply
Compounded prescription injection
NAD+
$299 for a one-month supply
Prescription injection

Every prescription price includes the telehealth consultation with a licensed physician. There is no membership fee. If the physician decides a treatment is not right for you, you do not pay for it.

Sermorelin, NAD+ and glutathione are compounded medications, as are our semaglutide and tirzepatide. Compounded medications are not FDA-approved, and the FDA has not reviewed them for safety or effectiveness. NMN is a dietary supplement. These statements have not been evaluated by the Food and Drug Administration, and the product is not intended to diagnose, treat, cure or prevent any disease.

So, where do you start?

You do not need all seven. You need the one that answers your question.

Tired, and nobody has ever checked your B12? Start there. It is $25.

Want your cells to have what they had at 30? That is NAD+, or NMN if price comes first.

Sleep and recovery? Sermorelin.

The waistline, and what it is doing to your heart? A GLP-1 medication.

What if aging well is not one big decision? What if it is one good question at a time?

At Goprolean, a licensed physician reviews your medical intake and decides whether a treatment is right for you. Prices run from $25 to $299 for a one-month supply, with the telehealth consultation included.

See everything in longevity · See weight loss programs

Keep reading: Benefits of B12 Shots: What If You Are Not Tired, Just Running Low? · NAD+ Injections and Aging: What If You Never Ran Low? · NMN vs NAD+: What If You Skipped the Ingredient and Took the Real Thing? · Glutathione Injections: What If You Could Refill Your Master Antioxidant? · Sermorelin and Aging: What If Your Body Only Needed a Nudge? · Do GLP-1 Medications Slow Aging? What the Research Shows · Metformin for Longevity: What If It Was Never Meant to Work Alone?

Questions people ask

What is longevity medicine?

Longevity medicine is care aimed at how well you age, not only at illness once it arrives. The goal is healthspan: the years you spend strong, clear-headed and independent. In practice it means finding what is changing with age, such as your energy, sleep, muscle or blood sugar, and working on that.

What is a longevity doctor?

A longevity doctor is a physician who focuses on prevention and on how you age, in place of waiting for a disease to treat. You do not need a clinic visit to see one. At Goprolean a licensed physician reviews your medical history online before anything is prescribed, and that consultation is included in the price.

Is there an FDA-approved longevity drug?

No. No medicine is approved to slow aging, and aging is not classed as a disease. Metformin is approved for type 2 diabetes, and using it for healthy aging is off-label. The manufacturers' versions of semaglutide and tirzepatide are approved for diabetes and for weight management, not for aging. Compounded medications, including ours, are not FDA-approved.

What is the best longevity treatment?

There is no single best one, because they do different things. B12 is for people running low. NAD+ and NMN are about the energy and repair inside your cells. Sermorelin is about sleep, recovery and muscle. GLP-1 medications are about weight, the heart and blood sugar. The best one is the one that matches what you want to change.

What is the best pill for anti-aging?

Of the seven treatments in this guide, two are taken by mouth. Metformin is a prescription pill with a long safety record. NMN is a supplement capsule your body turns into NAD+. Neither has been shown to slow aging in people. Metformin is $25 and NMN is $55 for a month at Goprolean.

Do longevity treatments really work?

Some do specific things that are well proven. In one large trial, semaglutide cut heart attacks, strokes and heart deaths by about 20% in adults with overweight or obesity and heart disease. B12 shots correct a B12 shortage. Whether any treatment slows aging itself in a healthy person is not yet known, because that trial would take decades. Not proven does not mean disproven.

What is the best peptide for longevity?

Sermorelin is the peptide we prescribe. It is a chain of 29 building blocks, a copy of the working part of your brain's own growth hormone release signal. In small studies of older adults it raised growth hormone within weeks. Nobody has shown that it adds years to a life. Semaglutide and tirzepatide are peptides too, and they are the ones with large trials behind them.

Can you combine longevity treatments?

Some are commonly paired. Metformin can lower B12 over time, so the two go together. We think metformin makes the most sense alongside NAD+ and a GLP-1 medication. Nobody has tested a full stack in people, so start with one treatment and add only what has a reason to be there. A physician reviews everything you take first.

How much does longevity medicine cost?

At Goprolean, from $25 to $299 for a one-month supply, depending on the treatment. B12 and metformin are $25. Glutathione is $57.32, sermorelin $195 and NAD+ $299. Every prescription price includes the telehealth consultation with a licensed physician, and there is no membership fee.

Do you need a prescription?

For six of the seven, yes. B12, NAD+, glutathione, sermorelin, GLP-1 medications and metformin are prescribed only after a licensed physician reviews your medical history. NMN is a dietary supplement and needs no prescription.

Sources

This article is general health information and is not medical advice for any individual. NMN is a dietary supplement. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Compounded medications are not FDA-approved and are not reviewed by the FDA for safety or effectiveness. Prescriptions are issued only after a medical intake is reviewed by a licensed physician, who may determine that treatment is not appropriate; in that case you are not charged for it. Individual results vary. Goprolean is operated by Prolean Wellness Management LLC, owner of Prolean Wellness in Scottsdale, Arizona. Care is provided by independent licensed clinicians.

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